According to the Xinhua News Agency, Shanghai, March 23, the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and the Garvan Institute of Medical Research in Australia have recently discovered several active compounds with therapeutic prospects for the treatment of diabetes. The joint research results of both parties were published in the latest issue of the internationally renowned academic journal Chemicals and Biology.
There are many researches on the chemical constituents and pharmacological activities of bitter gourd in modern times, but the main chemical substances and their mechanism of action of hypoglycemic are still not clear. The research group of Ye Yang, the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, conscientiously summarized the literature and previous research results. Through years of exploration, a series of new natural chemical components were isolated and identified from bitter gourd, and they cooperated with the Galvin Institute on cells and At the animal level, it has been clearly established for the first time that these natural components in plants have a blood glucose lowering activity.
Studies on the mechanism of hypoglycemic effects of compounds have shown that these compounds can activate an important protein involved in energy metabolism in vivo, namely adenosine monophosphate-activated protein kinase (AMPK), which has the function of regulating energy metabolism and promoting glucose uptake in the human body. . Taking effective measures to activate adenosine monophosphate-activated protein kinase (AMPK) is an important approach for the treatment of type 2 diabetes.