 |
Figure: Photothermal near-field enhancement of Au-Cu1.8S and absorption enhancement
As an important semiconductor material, copper-based sulfide nanocrystals have received extensive attention in the areas of photoelectricity, sensing, and energy conversion. In recent years, studies have found that non-stoichiometric Cu2-xS nanocrystals exhibit strong plasmon resonance absorption properties in the near-infrared region, and this unique optical property can be regulated by defect density in the crystal, particle size, and morphology. As a result, it has an excellent application prospect in the field of biomedicine.
In recent years, Jiang Jiang researcher of the Institute of Nanotechnology and Nanobionics of the Chinese Academy of Sciences Jiang Jiang has made a series of progresses in the preparation and performance study of copper-based sulfides. Based on the previous alloy vulcanization preparation of precious metal-copper sulfide composite system (J. Mater. Chem., 2012, 22, 23169-23174; J. Mater. Chem. A, 2013, 1, 11880-11886), based on optimization The synthesis process enables controllable growth of self-doped copper sulfide (Cu1.8S) nanocrystals on nanogold.
The high-purity Au-Cu1.8S composite nanocrystals were obtained by precise control of the corresponding experimental parameters and copper-sulfur ratio in the solvothermal reaction. The experimental and related theoretical simulation results show that the Au nanocrystals significantly enhance the plasmon resonance absorption of Cu1.8S, which in turn makes the photothermal effect of the Au-Cu1.8S composite nanocrystals the same for the mass Au and Cu1.8S physical mixed solution 1.5 Times.
The excitation was performed by using a light source with a near-infrared two-zone window. The in vitro simulation data demonstrated that an effective photothermotherapy can be achieved at an epidermis depth of 5 mm. The cytotoxicity, photothermic effects of both cells and living organisms showed excellent photothermotherapy properties in the near infrared two-zone window. In addition, the existence of nanogold also gives this material a CT imaging function, enabling it to serve as an integral diagnostic and treatment reagent in individualized medicine. This is the first report on the use of laser intensity lower than the safe use of lasers in the study of phototherapy of cancer in the near-infrared region. The results were published in J. Am. Chem. Soc. 2014, 136, 15684−15693.
In addition, in addition to the binary Cu2-xS nanocrystals, the research group has also made a series of advances in the study of controllable preparation and formation mechanism of multicomponent CuSbS2 and Cu2ZnSnS4 nanocrystals (J. Am. Chem. Soc., 2013, 135, 18377–18384; Mater. Lett., 2014, 123, 66-69).
The above work has received strong support from the "Hundred Talents Program" of the Chinese Academy of Sciences and the National Natural Science Foundation.
Water Pump,Electric Water Pump,Small Water Pump,Domestic Water Pumps
Ebic Tools Limited , http://www.ebictools.com